Catalog No.: PC-21897Not For Human Use, Lab Use Only.
Maraviroc (UK-427857) is a potent, selective and orally bioavailable CCR5 inhibitor with IC50 of 3.3 nM, 7.2 nM and 5.2 nM for MIP-1α, MIP-1β and RANTES binding to cell membrane preparations of CCR5-expressing HEK-293, shows broad-spectrum activity against HIV-1.
Maraviroc (UK-427857) is a potent, selective and orally bioavailable CCR5 inhibitor with IC50 of 3.3 nM, 7.2 nM and 5.2 nM for MIP-1α, MIP-1β and RANTES binding to cell membrane preparations of CCR5-expressing HEK-293, shows broad-spectrum activity against HIV-1. Maraviroc (UK-427857) shows potent antiviral activity against the 43 primary CCR5-tropic HIV-1 isolates with a geometric mean IC90 of 2.0 nM. Maraviroc (UK-427857) does not affect CCR5 cell surface levels or associated intracellular signaling. Maraviroc (UK-427857) has no detectable in vitro cytotoxicity and is highly selective for CCR5, as confirmed against a wide range of receptors and enzymes, including the hERG ion channel.
