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Marizomib

Chemical Structure : Marizomib

CAS No.: 437742-34-2

Marizomib (NPI 0052, Salinosporamide A)

Catalog No.: PC-61315Not For Human Use, Lab Use Only.

Marizomib (NPI 0052, Salinosporamide A) is a potent, orally bioactive 20S proteasome inhibitor with IC50 of 1.3 nM (inhibition of proteasomal chymotrypsin-like proteolytic activity).

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Biological Activity

Marizomib (NPI 0052, Salinosporamide A) is a potent, orally bioactive 20S proteasome inhibitor with IC50 of 1.3 nM (inhibition of proteasomal chymotrypsin-like proteolytic activity).
Marizomib displays 35 times more potent than omuralide; induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib, including chemical structure, effects on proteasome activities, mechanisms of action, and toxicity profile against normal cells.
Marizomib significantly reduces tumor recurrence in animal tumor model studies.

Physicochemical Properties

M.Wt 313.781
Formula C15H20ClNO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1R,4R,5S)-4-(2-Chloroethyl)-1-[(S)-(1S)-2-cyclohexen-1-ylhydroxymethyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

References

1. Chauhan D, et al. Cancer Cell. 2005 Nov;8(5):407-19.

2. Feling RH, et al. Angew Chem Int Ed Engl. 2003 Jan 20;42(3):355-7.

3. Ruiz S, et al. Mol Cancer Ther. 2006 Jul;5(7):1836-43.

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