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Chemical Structure : Marizomib
CAS No.: 437742-34-2
Catalog No.: PC-61315Not For Human Use, Lab Use Only.
Marizomib (NPI 0052, Salinosporamide A) is a potent, orally bioactive 20S proteasome inhibitor with IC50 of 1.3 nM (inhibition of proteasomal chymotrypsin-like proteolytic activity).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 500 ug | $298 | In stock | |
| 1 mg | $478 | In stock | |
| 5 mg | $898 | In stock | |
| 10 mg | Get quote | ||
| 25 mg | Get quote |
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Marizomib (NPI 0052, Salinosporamide A) is a potent, orally bioactive 20S proteasome inhibitor with IC50 of 1.3 nM (inhibition of proteasomal chymotrypsin-like proteolytic activity).
Marizomib displays 35 times more potent than omuralide; induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib, including chemical structure, effects on proteasome activities, mechanisms of action, and toxicity profile against normal cells.
Marizomib significantly reduces tumor recurrence in animal tumor model studies.
| M.Wt | 313.781 | |
| Formula | C15H20ClNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1R,4R,5S)-4-(2-Chloroethyl)-1-[(S)-(1S)-2-cyclohexen-1-ylhydroxymethyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione |
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1. Chauhan D, et al. Cancer Cell. 2005 Nov;8(5):407-19.
2. Feling RH, et al. Angew Chem Int Ed Engl. 2003 Jan 20;42(3):355-7.
3. Ruiz S, et al. Mol Cancer Ther. 2006 Jul;5(7):1836-43.
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