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Chemical Structure : Mesdopetam
Catalog No.: PC-47114Not For Human Use, Lab Use Only.
Mesdopetam (IRL790) is a novel dopamine transmission modulator and dopamine D3 receptor antagonist with Ki/IC50 of 0.09/0.41 uM.
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Mesdopetam (IRL790) is a novel dopamine transmission modulator and dopamine D3 receptor antagonist with Ki/IC50 of 0.09/0.41 uM.
IRL790 also shows sub-micromolar affinities at DA D2 and σ1 receptors, and micromolar affinities at 5-HT1a, 5-HT2a, and 5-HT7 receptors, does not show any agonist-like properties at D2, D3, 5-HT2, or 5-HT7 receptors.
IRL790 displays balancing effects on aberrant motor phenotypes, reducing l-DOPA-induced dyskinesias in the rodent 6-hydroxydopamine lesion model and reducing psychostimulant-induced locomotor hyperactivity elicited by pretreatment with either d-amphetamine or dizocilpine, without negatively impacting normal motor performance.
IRL790 is active in models of perturbed dopaminergic and glutamatergic signaling, including rodent 6-hydroxydopamine l-DOPA-induced dyskinesias and psychostimulant-induced hyperactivity, in a dose range that does not impair normal behavior.
| M.Wt | 275.338 | |
| Formula | C12H18FNO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Waters S, et al. J Pharmacol Exp Ther. 2020 Jul;374(1):113-125.
2. Becanovic K, et al. J Pharmacol Exp Ther. 2020 Jul;374(1):126-133.
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