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Chemical Structure : Methoxy-PEPy
CAS No.: 524924-76-3
Catalog No.: PC-43079Not For Human Use, Lab Use Only.
Methoxy-PEPy is a potent, selective mGlu5 receptor antagonist with IC50 of 1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Methoxy-PEPy is a potent, selective mGlu5 receptor antagonist with IC50 of 1 nM; exhibits 14-fold higher binding in forebrain relative to cerebellum in mGlu5 receptor-deficient mice, the radioligand [3H]methoxy-PEPy is useful for determining the occupancy of mGlu5 receptors in the brain.
| M.Wt | 210.2313 | |
| Formula | C13H10N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pyridine, 3-methoxy-5-[2-(2-pyridinyl)ethynyl]- |
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1. Cosford ND, et al. Bioorg Med Chem Lett. 2003 Feb 10;13(3):351-4.
2. Anderson JJ, et al. Eur J Pharmacol. 2003 Jul 18;473(1):35-40.
3. Salisbury BG, et al. Eur J Pharmacol. 2008 Jan 28;579(1-3):34-9.
4. Hellyer SD, et al. Mol Pharmacol. 2018 Mar 7. pii: mol.117.111518.
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