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Methylene Blue

Chemical Structure : Methylene Blue

CAS No.: 61-73-4

Methylene Blue (Basic Blue 9, CI-52015, Methylthioninium chloride)

Catalog No.: PC-23175Not For Human Use, Lab Use Only.

Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor, also is a Tau aggregation inhibitor, inhibits DENV NS2B-NS3 inhibitor (IC50=9 µM) and DENV infection in cells in the submicromolar range (EC50=0.36 µM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor, also is a Tau aggregation inhibitor, inhibits DENV NS2B-NS3 inhibitor (IC50=9 µM) and DENV infection in cells in the submicromolar range (EC50=0.36 µM).

Physicochemical Properties

M.Wt 319.85
Formula C16H18ClN3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

References

1. Lorenzo Cavina, et al. Molecules. 2024 Aug 27;29(17):4047.

2. Klamer D, et, al. Basic Clin Pharmacol Toxicol. 2004 Feb;94(2):65-72.

3. Fenn AM, et, al. J Neurotrauma. 2015 Jan 15;32(2):127-38.

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