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Metoclopramide hydrochloride hydrate

Chemical Structure : Metoclopramide hydrochloride hydrate

CAS No.: 54143-57-6

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Metoclopramide hydrochloride hydrate

Catalog No.: PC-45205Not For Human Use, Lab Use Only.

A potent dopamine D2 receptor antagonist with Ki of 28 nM.

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500 mg $96 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent dopamine D2 receptor antagonist with Ki of 28 nM; also is a mixed 5-HT3 receptor antagonist/5-HT4 receptor agonist; commonly used to treat nausea and vomiting caused by chemotherapy.

Chemotherapeutic Agents

Phase 2 Discontinued

Physicochemical Properties

M.Wt 354.2726
Formula C14H25Cl2N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-, hydrochloride, hydrate (1:1:1)

References

1. Matsui A, et al. J Pharmacol Exp Ther. 1998 Nov;287(2):725-32.

2. Tonini M, et al. Pharmacol Res. 1995 May;31(5):257-60.

3. Bateman DN, et al. Br J Clin Pharmacol. 1978 Nov;6(5):401-7.

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