Micheliolide

Chemical Structure : Micheliolide

CAS No.: 68370-47-8

Catalog No.: PC-23535Not For Human Use, Lab Use Only.

Packing	Price	Stock
1 mg	$48	In stock
5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$358	In stock
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Micheliolide (MCL) is a potent, selective and allosteric activator of PKM2, selectively activates pyruvate kinase M2 (PKM2) through the covalent binding at Cys424, effectively promotes the pyruvate kinase activity of rPKM2 with AC50 of 6 nM, shows broad-spectrum anticancer and anti-inflammation activity.
Micheliolide (MCL) selectively inhibits acute myelogenous leukemia stem and progenitor cells.
Micheliolide (MCL) inhibited NF-κB activation and subsequent pro-inflammatory pathways activation in vitro and in vivo.
Micheliolide inhibits LPS-induced inflammatory response and protects mice from LPS challenge.
Micheliolide provides protection of mice against Staphylococcus aureus and MRSA infection by down-regulating inflammatory response.

Physicochemical Properties

M.Wt	248.32
Formula	C15H20O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Azuleno[4,5-b]furan-2(3H)-one, 3a,4,5,7,8,9,9a,9b-octahydro-9-hydroxy-6,9-dimethyl-3-methylene-, (3aS,9R,9aS,9bS)-

References

1. Zhang Q, et al. J Med Chem. 2012 Oct 25;55(20):8757-69.

2. Li J, et al. J Med Chem. 2018 May 10;61(9):4155-4164.

3. Jiang X, et al. Sci Rep. 2017 Feb 6;7:41964.

4. Viennois E, et al. Lab Invest. 2014 Sep;94(9):950-65.

Micheliolide

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.