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Miclxin

Chemical Structure : Miclxin

CAS No.: 2494198-61-5

Miclxin (DS37262926)

Catalog No.: PC-38409Not For Human Use, Lab Use Only.

Miclxin (DS37262926) is a small molecule inhibitor of MICOS component MIC60, induces mitochondrial stress response in a mutant β-catenin-dependent manner in β-catenin-mutated HCT116 cells, directly binds to mitochondrial inner membrane complex protein MIC60 (SPR Kd=11.9 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Miclxin (DS37262926) is a small molecule inhibitor of MICOS component MIC60, induces mitochondrial stress response in a mutant β-catenin-dependent manner in β-catenin-mutated HCT116 cells, directly binds to mitochondrial inner membrane complex protein MIC60 (SPR Kd=11.9 uM).
Miclxin (DS37262926) exhibits selective induction of apoptosis in β-catenin-mutated HCT116 cells, which harbor deletion mutant of Ser45. Mutation at Ser45 of β-catenin is detected not only in colorectal tumor but in hepatocellular, prostate and uterine tumors. Miclxin-mediated MIC60 dysfunction induced mitochondrial stress response, leading to apoptosis-inducing factor (AIF)-dependent apoptosis.

Physicochemical Properties

M.Wt 441.535
Formula C26H27N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-methoxy-N-(3-methoxybenzyl)-2-(3-(pyridin-3-yl)pyrrolidin-1-yl)quinazolin-4-amine

References

1. Hiroaki Ikeda, et al. ACS Chem Biol. 2020 Aug 21;15(8):2195-2204.

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