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Miglustat hydrochloride

Chemical Structure : Miglustat hydrochloride

CAS No.: 210110-90-0

Miglustat hydrochloride (NB-DNJ hydrochloride, OGT-918 hydrochloride)

Catalog No.: PC-45142Not For Human Use, Lab Use Only.

Miglustat hydrochloride (N-Butyldeoxynojirimycin, SC-48334, NB-DNJ, OGT-918) is an orally active and reversible inhibitor of glucosylceramide synthase (GCS, ceramide glucosyltransferase).

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Biological Activity

Miglustat hydrochloride (N-Butyldeoxynojirimycin, SC-48334, NB-DNJ, OGT-918) is an orally active and reversible inhibitor of glucosylceramide synthase (GCS, ceramide glucosyltransferase).
Miglustat inhibits glycolipid biosynthesis, has no effect on the maturation of N-linked oligosaccharides or on lysosomal glucocerebrosidase.
Miglustat is used primarily to treat type I Gaucher disease (GD1).

Physicochemical Properties

M.Wt 255.739
Formula C10H22ClNO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: ≥ 34 mg/mL

Chemical Name/SMILES

3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, hydrochloride (1:1), (2R,3R,4R,5S)-

References

1. Platt FM, et al. J Biol Chem. 1994 Oct 28;269(43):27108-14.

2. D'Arcangelo G, et al. Neural Plast. 2016;2016:3830424.

3. Fischer PB, et al. J Virol. 1995 Sep;69(9):5791-7.

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