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Miricorilant

Chemical Structure : Miricorilant

CAS No.: 1400902-13-7

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Miricorilant (CORT118335)

Catalog No.: PC-25606Not For Human Use, Lab Use Only.

Miricorilant (CORT118335) is a potent, selective glucocorticoid receptor (GR) antagonist with binding Ki of 8 nM, selective over estrogen (ERα), androgen (AR) and progesterone (PR) receptors.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Miricorilant (CORT118335) is a potent, selective glucocorticoid receptor (GR) antagonist with binding Ki of 8 nM, selective over estrogen (ERα), androgen (AR) and progesterone (PR) receptors.
Miricorilant (CORT118335) is efficacious when dosed orally in an olanzapine-induced weight gain model in rats.

Physicochemical Properties

M.Wt 428.46
Formula C24H23F3N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-((1r,4r)-4-phenylcyclohexyl)-5-(3-(trifluoromethyl)benzyl)pyrimidine-2,4(1H,3H)-dione

References

1. Hunt HJ, et al. J Clin Psychopharmacol. 2021 Nov-Dec 01;41(6):632-637.

2. Hunt HJ, et al. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7376-80.

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