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MitoBloCK 1

Chemical Structure : MitoBloCK 1

CAS No.: 373370-73-1

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MitoBloCK 1 (MitoBloCK1)

Catalog No.: PC-62047Not For Human Use, Lab Use Only.

MitoBloCK 1 is a small molecule inhibitor that blocks the import of substrates that use the TIM22 import pathway, but not TIM23 or the Mia40/Erv1 translocation pathways.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MitoBloCK 1 is a small molecule inhibitor that blocks the import of substrates that use the TIM22 import pathway, but not TIM23 or the Mia40/Erv1 translocation pathways.
    MitoBloCK 1 also inhibits growth of mammalian cells and import of the ADP/ATP carrier, but not TIM23 substrates.
    MitoBloCK 1 is an useful chemical tool for investigation mammalian mitochondrial import and dysfunction linked to inherited human disease.

    Physicochemical Properties

    M.Wt 368.249
    Formula C14H14BrN3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((3-bromo-2-hydroxy-6,7,8,9-tetrahydrodibenzo[b,d]furan-1-yl)methylene)hydrazine-1-carbothioamide

    References

    1. Hasson SA, et al. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9578-83.

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