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MitoBloCK 6

Chemical Structure : MitoBloCK 6

CAS No.: 303215-67-0

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MitoBloCK 6 (MitoBloCK6)

Catalog No.: PC-62048Not For Human Use, Lab Use Only.

MitoBloCK 6 is a small molecule mitochondrial protein import blocker that inhibits Erv1 oxidase activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MitoBloCK 6 is a small molecule mitochondrial protein import blocker that inhibits Erv1 oxidase activity.
MitoBloCK 6 attenuates the import of Erv1 substrates into yeast mitochondria and inhibited oxidation of Tim13 and Cmc1 in in vitro reconstitution assays.
MitoBloCK 6 impairs the cardiac development in zebrafish embryos, induces apoptosis via cytochrome c release in human embryonic stem cells (hESCs) but not in differentiated cells

Physicochemical Properties

M.Wt 357.234
Formula C19H14Cl2N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,4-dichloro-6-(((4-(phenylamino)phenyl)imino)methyl)phenol

References

1. Dabir DV, et al. Dev Cell. 2013 Apr 15;25(1):81-92.

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