Mps1-IN-3 |CAS:1609584-72-6 Probechem Biochemicals

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Chemical Structure : Mps1-IN-3

CAS No.: 1609584-72-6

Mps1-IN-3 (MPS1 inhibitor 3)

Catalog No.: PC-43017Not For Human Use, Lab Use Only.

Mps1-IN-3 is a selective and highly potent Mps1 kinase inhibitor with IC50 of 50 nM.

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25 mg	$158	In stock
50 mg	$258	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Mps1-IN-3 is a selective and highly potent Mps1 kinase inhibitor with IC50 of 50 nM.
Mps1-IN-3 causes mitotic aberrancies in glioblastoma cells and, in combination with vincristine, induces mitotic checkpoint override, increases aneuploidy and augmentes cell death.
Mps1-IN-3 sensitizes glioblastoma cells to vincristine in orthotopic mouse models, resulting in prolonged survival without toxicity.

Physicochemical Properties

M.Wt	537.6339
Formula	C26H31N7O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Piperidinol, 1-[3-methoxy-4-[[6-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-9H-purin-2-yl]amino]phenyl]-

References

1. Tannous BA, et al. J Natl Cancer Inst. 2013 Sep 4;105(17):1322-31.

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Mps1-IN-3 (MPS1 inhibitor 3)

Biological Activity

Physicochemical Properties

References

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