Catalog No.: PC-62240Not For Human Use, Lab Use Only.
Mps1 inhibitor 2 (Mps1-IN-2) is a potent, selective Mps1 kinase inhibitor with IC50 of 145 nM, demonstrates >1,000-fold selectivity over a panel of 352 kinases with the major exceptions of Gak and Plk1.
Mps1 inhibitor 2 (Mps1-IN-2) is a potent, selective Mps1 kinase inhibitor with IC50 of 145 nM, demonstrates >1,000-fold selectivity over a panel of 352 kinases with the major exceptions of Gak and Plk1.
Mps1-IN-2 treratment leads to defects in Mad1 and Mad2 establishment at unattached kinetochores, decreases Aurora B kinase activity, premature mitotic exit and gross aneuploidy, without any evidence of centrosome duplication defects; decreases cancer cell viability.
