Mps1 inhibitor G17

Chemical Structure : Mps1 inhibitor G17

Catalog No.: PC-27877Not For Human Use, Lab Use Only.

Mps1 inhibitor G17 is a selective inhibitor of monopolar spindle 1 (Mps1) with IC50 of 75.5 nM, >30-fold selectivity over TLK1, disrupts spindle assembly checkpoint (SAC) signaling in glioblastoma.

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Biological Activity

Mps1 inhibitor G17 is a selective inhibitor of monopolar spindle 1 (Mps1) with IC50 of 75.5 nM, >30-fold selectivity over TLK1, disrupts spindle assembly checkpoint (SAC) signaling in glioblastoma.

Physicochemical Properties

M.Wt	557.72
Formula	C30H35N7O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1r,4r)-4-((2-((10-(2-morpholinoethyl)-10H-phenothiazin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexan-1-ol

References

1. Rai G, et al. J Biol Chem. 2026 Aug 25:113487.

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