Chemical Structure : Myc modulator DL78
CAS No.:
132993-79-4
Myc modulator DL78
Catalog No.: PC-25645Not For Human Use, Lab Use Only.
Myc modulator DL78 is a small molecule Myc modulator and potent antimitotic agent with selective anticancer activity, disrupts Myc and α-tubulin interaction and preferentially targets chromosomally unstable, MYC-overexpressing cancer cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Myc modulator DL78 is a small molecule Myc modulator and potent antimitotic agent with selective anticancer activity, disrupts Myc and α-tubulin interaction and preferentially targets chromosomally unstable, MYC-overexpressing cancer cells.
DL78 sensitizes platinum-resistant cells to cisplatin and induces apoptosis following mitotic catastrophe.
High Myc-expressing cancer cells are selectively sensitive to DL78.
DL78 (50 mg/kg IP) significantly decreased overall tumor burden and metastatic spread in NSG mice injected intraperitoneally with OV81.2 cells.
DL78 induces cancer-selective mitotic catastrophe by disrupting Myc's interaction with α-tubulin rather than its transcriptional activity.
Physicochemical Properties
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M.Wt
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336.34
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Formula
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C20H16O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(5-methoxy-2-methylbenzofuran-3-yl)(5-methoxybenzofuran-2-yl)methanone
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References
1. Teitel J, et al. Sci Rep. 2025 Oct 31;15(1):38188.
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