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Chemical Structure : Mycro3
CAS No.: 944547-46-0
Catalog No.: PC-38503Not For Human Use, Lab Use Only.
Mycro3 is a selective small molecule inhibitor of Myc/Max dimerization with IC50 of 40 uM with a cognate-binding site, inhibits DNA binding of c-Myc with preference over other dimeric transcription factors in vitro.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | $788 | In stock | |
| 1 g | Get quote |
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Mycro3 is a selective small molecule inhibitor of Myc/Max dimerization with IC50 of 40 uM with a cognate-binding site, inhibits DNA binding of c-Myc with preference over other dimeric transcription factors in vitro.
Mycro3 inhibits c-Myc-dependent proliferation, gene transcription, and oncogenic transformation in the low micromolar concentration range.
Mycro3 inhibits c-Myc-dependent gene transcription and c-Myc-dependent anchorage-independent growth.
Mycro3 drastically attenuated in Mycro3-treated NOD/SCID mice carrying orthotopic or heterotopic xenografts of human pancreatic cancer cells.
| M.Wt | 526.88 | |
| Formula | C24H17ClF2N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Ethyl 5-[[[7-(chlorodifluoromethyl)-5-(2-furanyl)pyrazolo[1,5-a]pyrimidin-2-yl]carbonyl]amino]-1-phenyl-1H-pyrazole-4-carboxylate |
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1. Bonham AJ, et al. Nucleic Acids Res. 2013 Jan;41(2):754-63.
2. Stellas D, et al. J Natl Cancer Inst. 2014 Oct 11;106(12):dju320.
3. Anke Kiessling, et al. Chem Biol. 2006 Jul;13(7):745-51.
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