Catalog No.: PC-38503Not For Human Use, Lab Use Only.
Mycro3 is a selective small molecule inhibitor of Myc/Max dimerization with IC50 of 40 uM with a cognate-binding site, inhibits DNA binding of c-Myc with preference over other dimeric transcription factors in vitro.
Mycro3 is a selective small molecule inhibitor of Myc/Max dimerization with IC50 of 40 uM with a cognate-binding site, inhibits DNA binding of c-Myc with preference over other dimeric transcription factors in vitro.
Mycro3 inhibits c-Myc-dependent proliferation, gene transcription, and oncogenic transformation in the low micromolar concentration range.
Mycro3 inhibits c-Myc-dependent gene transcription and c-Myc-dependent anchorage-independent growth.
Mycro3 drastically attenuated in Mycro3-treated NOD/SCID mice carrying orthotopic or heterotopic xenografts of human pancreatic cancer cells.
