Catalog No.: PC-62579Not For Human Use, Lab Use Only.
N-acetyl lysyltyrosylcysteine amide (KYC) is a potent, tripeptide inhibitor of myeloperoxidase (MPO), inhibits MPO-mediated hypochlorous acid (HOCl) formation (IC50=7 uM) and nitration/oxidation of LDL.
N-acetyl lysyltyrosylcysteine amide (KYC) is a potent, tripeptide inhibitor of myeloperoxidase (MPO), inhibits MPO-mediated hypochlorous acid (HOCl) formation (IC50=7 uM) and nitration/oxidation of LDL.
N-acetyl lysyltyrosylcysteine amide completely inhibits HOCl production at 25 uM, decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice.
N-acetyl lysyltyrosylcysteine amide reduces oxidative stress-mediated inflammation, neuronal damage, and neural stem cell injury in murine model of stroke.
Physicochemical Properties
M.Wt
453.56
Formula
C20H31N5O5S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
100 mM in H2O
Chemical Name/SMILES
N-acetyl lysyltyrosylcysteine amide
References
1. Zhang H, et al. J Lipid Res. 2013 Nov;54(11):3016-29.
2. Zhang H, et al. J Lipid Res. 2013 Nov;54(11):3009-15.
3. Yu G, et al. J Neuroinflammation. 2016 May 24;13(1):119.
4. Rymaszewski AL, et al. Cancers (Basel). 2014 May 9;6(2):1111-27.
