Chemical Structure : N-arachidonylglycine
CAS No.: 179113-91-8
Catalog No.: PC-27609Not For Human Use, Lab Use Only.
N-Arachidonylglycine (NAGly, NA-Gly) is a carboxylic analog of the endocannabinoid anandamide (AEA) and endogenous ligand/agonist of GPR18 with EC50 of 44.5 nM, also is a endogenous agaonist of orphan G protein-coupled receptor GPR92 with EC50 of 4.47 uM.
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|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $188 | In stock | |
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N-Arachidonylglycine (NAGly, NA-Gly) is a carboxylic analog of the endocannabinoid anandamide (AEA) and endogenous ligand/agonist of GPR18 with EC50 of 44.5 nM, also is a endogenous agaonist of orphan G protein-coupled receptor GPR92 with EC50 of 4.47 uM.
N-Arachidonylglycine is present in bovine and rat brain as well as other tissues and that it suppresses tonic inflammatory pain.
N-Arachidonylglycine is also a reversible and non-competitive inhibitor of glycine transport by GLYT2a, but has little effect on glycine transport by GLYT1b or gamma-amino butyric acid transport by GAT1.
| M.Wt | 361.53 | |
| Formula | C22H35NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamido)acetic acid |
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1. Oh DY, et al. J Biol Chem. 2008 Jul 25;283(30):21054-64.
2. Ikeda Y, et al. Biochem Biophys Res Commun. 2005 Aug 5;333(3):778-86.
3. Huang SM, et al. J Biol Chem. 2001 Nov 16;276(46):42639-44.
4. Wiles AL, et al. J Neurochem. 2006 Nov;99(3):781-6.

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