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N-arachidonylglycine

Chemical Structure : N-arachidonylglycine

CAS No.: 179113-91-8

N-arachidonylglycine (NAGly, NA-Gly)

Catalog No.: PC-27609Not For Human Use, Lab Use Only.

N-Arachidonylglycine (NAGly, NA-Gly) is a carboxylic analog of the endocannabinoid anandamide (AEA) and endogenous ligand/agonist of GPR18 with EC50 of 44.5 nM, also is a endogenous agaonist of orphan G protein-coupled receptor GPR92 with EC50 of 4.47 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

N-Arachidonylglycine (NAGly, NA-Gly) is a carboxylic analog of the endocannabinoid anandamide (AEA) and endogenous ligand/agonist of GPR18 with EC50 of 44.5 nM, also is a endogenous agaonist of orphan G protein-coupled receptor GPR92 with EC50 of 4.47 uM.
N-Arachidonylglycine is present in bovine and rat brain as well as other tissues and that it suppresses tonic inflammatory pain.
N-Arachidonylglycine is also a reversible and non-competitive inhibitor of glycine transport by GLYT2a, but has little effect on glycine transport by GLYT1b or gamma-amino butyric acid transport by GAT1.

Physicochemical Properties

M.Wt 361.53
Formula C22H35NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamido)acetic acid

References

1. Oh DY, et al. J Biol Chem. 2008 Jul 25;283(30):21054-64.

2. Ikeda Y, et al. Biochem Biophys Res Commun. 2005 Aug 5;333(3):778-86.

3. Huang SM, et al. J Biol Chem. 2001 Nov 16;276(46):42639-44.

4. Wiles AL, et al. J Neurochem. 2006 Nov;99(3):781-6.

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