Catalog No.: PC-61908Not For Human Use, Lab Use Only.
N1-hexyl-N5-benzyl-biguanide mesylate (HBB) is a potent and specific inhibitor of CYP3A4 AA epoxygenase activity with IC50 of 9.5 uM for inhibition of CYP3A4-mediated (±)-14,15-EET synthesis.
N1-hexyl-N5-benzyl-biguanide mesylate (HBB) is a potent and specific inhibitor of CYP3A4 AA epoxygenase activity with IC50 of 9.5 uM for inhibition of CYP3A4-mediated (±)-14,15-EET synthesis.
HBB displays significantly higher for CYP2C8 (IC50=45 uM), and does not inhibit the AA epoxygenase activity of CYP2J2.
HBB inhibits MCF-7 cell line and ER+ and triple-negative breast cancer cell lines with similar IC50 (20 uM).
HBB strongly inhibits the oxygen consumption rate (OCR) and suppresses ATP stores, rapidly activates pAMPK and inhibits Stat3, mTOR, and ERK.
HBB inhibits MCF-7 xenograft tumor growth (24 mg/kg/week i.p.).
Physicochemical Properties
M.Wt
371.5
Formula
C16H29N5O3S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N1-hexyl-N5-benzyl-biguanide mesylate
References
1. Guo Z, et al. Cell Chem Biol. 2017 Oct 19;24(10):1259-1275.e6.
