N205 | Antimalarial | Probechem Biochemicals

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Chemical Structure : N205

N205 (N-205, N 205)

Catalog No.: PC-35114Not For Human Use, Lab Use Only.

N205 is a novel anti-malaria compound with in vitro IC50 of 1.3 nM against Plasmodium falciparum (3D7).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

N205 is a novel anti-malaria compound with in vitro IC50 of 1.3 nM against Plasmodium falciparum (3D7).
N205 demonstrates excellent rodent pharmacokinetic and in vivo antimalarial efficacy studies in the mouse Plasmodium berghei and Plasmodium falciparum Pf3D70087/N9 severe combined immunodeficiency (SCID) mouse models.

Physicochemical Properties

M.Wt	455.595
Formula	C27H37NO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-((1r,3r,5r,7r)-dispiro[adamantane-2,3'-[1,2,4,5]tetraoxane-6',1''-cyclohexan]-4''-yl)benzyl)morpholine

References

1. O' Neill PM, et al. Bioorg Med Chem. 2018 May 17. pii: S0968-0896(18)30203-7.

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N205 (N-205, N 205)

Biological Activity

Physicochemical Properties

References

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