Catalog No.: PC-70232Not For Human Use, Lab Use Only.
NAPQI (N-Acetylimidoquinone) is a toxic byproduct, iminoquinone metabolite of acetaminophen that covalently binds to the active site of macrophage migration inhibitory factor (MIF).
NAPQI (N-Acetylimidoquinone) is a toxic byproduct, iminoquinone metabolite of acetaminophen that covalently binds to the active site of macrophage migration inhibitory factor (MIF).
NAPQI inhibits both the isomerase and the biological activities of MIF with IC50 of 40 uM.
NAPQI significantly inhibits the ability of MIF to override the immunosuppressive effect of dexamethasone on endotoxin- (LPS) stimulated TNFα production by monocytes.
Physicochemical Properties
M.Wt
149.147
Formula
C8H7NO2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(4-oxocyclohexa-2,5-dien-1-ylidene)acetamide
References
1. Senter PD, et al. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):144-9.
2. Albano E, et al. Mol Pharmacol. 1985 Sep;28(3):306-11.
3. Crichlow GV, et al. Biochemistry. 2009 Jan 13;48(1):132-9.
