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NAcM-COV

Chemical Structure : NAcM-COV

CAS No.: 2089293-81-0

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NAcM-COV (DCN1 inhibitor NAcM-COV)

Catalog No.: PC-61932Not For Human Use, Lab Use Only.

NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays.
    NAcM-COV shows highly selectivity with respect to other protein acetyl-amide-binding sites.
    NAcM-COV inhibits NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification.

    Physicochemical Properties

    M.Wt 516.609
    Formula C28H35F3N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2-((1-(1-(pentan-2-yl)piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)ureido)methyl)phenyl)acrylamide

    References

    1. Scott DC, et al. Nat Chem Biol. 2017 Aug;13(8):850-857.

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