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Chemical Structure : NAcM-OPT
CAS No.: 2089293-61-6
Catalog No.: PC-61931Not For Human Use, Lab Use Only.
NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM in TR-FRET assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM in TR-FRET assays.
NAcM-OPT also inhibits DCN2, but has no activity against DCN3, DCN4, or DCN5.
NAcM-OPT inhibits NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification.
| M.Wt | 434.405 | |
| Formula | C23H29Cl2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea |
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1. Scott DC, et al. Nat Chem Biol. 2017 Aug;13(8):850-857.
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