NAcM-OPT |CAS:2089293-61-6 Probechem Biochemicals

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Chemical Structure : NAcM-OPT

CAS No.: 2089293-61-6

NAcM-OPT (DCN1 inhibitor NAcM-OPT)

Catalog No.: PC-61931Not For Human Use, Lab Use Only.

NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM in TR-FRET assays.

Packing	Price	Stock
25 mg	$128	In stock
50 mg	$198	In stock
100 mg	$328	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM in TR-FRET assays.
NAcM-OPT also inhibits DCN2, but has no activity against DCN3, DCN4, or DCN5.
NAcM-OPT inhibits NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification.

Physicochemical Properties

M.Wt	434.405
Formula	C23H29Cl2N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea

References

1. Scott DC, et al. Nat Chem Biol. 2017 Aug;13(8):850-857.

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NAcM-OPT (DCN1 inhibitor NAcM-OPT)

Biological Activity

Physicochemical Properties

References

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