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NB 001

Chemical Structure : NB 001

CAS No.: 686301-48-4

NB 001 (NB001, NB-001)

Catalog No.: PC-60666Not For Human Use, Lab Use Only.

NB 001 (NB001) is a potent, relatively selective and orally active adenylyl cyclase 1 (AC1) inhibitor with IC50 of 10 uM (cAMP production inhibition).

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Biological Activity

NB 001 (NB001) is a potent, relatively selective and orally active adenylyl cyclase 1 (AC1) inhibitor with IC50 of 10 uM (cAMP production inhibition).
NB 001 displays >10-fold selectivity over AC5/6/7/8.
NB 001 shows analgesic effect in animal models of neuropathic pain, without no significant effect on behavioral anxiety.

Physicochemical Properties

M.Wt 264.333
Formula C12H20N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-[[2-(6-amino-9H-purin-9-yl)ethyl]amino]-1-pentanol

References

1. Wang H, et al. Sci Transl Med. 2011 Jan 12;3(65):65ra3.

2. Brand CS, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):265-75.

3. Zhang MM, et al. Mol Brain. 2014 Jun 16;7:47.

4. Sethna F, et al. Nat Commun. 2017 Feb 20;8:14359.

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