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Chemical Structure : NB 001
Catalog No.: PC-60666Not For Human Use, Lab Use Only.
NB 001 (NB001) is a potent, relatively selective and orally active adenylyl cyclase 1 (AC1) inhibitor with IC50 of 10 uM (cAMP production inhibition).
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NB 001 (NB001) is a potent, relatively selective and orally active adenylyl cyclase 1 (AC1) inhibitor with IC50 of 10 uM (cAMP production inhibition).
NB 001 displays >10-fold selectivity over AC5/6/7/8.
NB 001 shows analgesic effect in animal models of neuropathic pain, without no significant effect on behavioral anxiety.
| M.Wt | 264.333 | |
| Formula | C12H20N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang H, et al. Sci Transl Med. 2011 Jan 12;3(65):65ra3.
2. Brand CS, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):265-75.
3. Zhang MM, et al. Mol Brain. 2014 Jun 16;7:47.
4. Sethna F, et al. Nat Commun. 2017 Feb 20;8:14359.
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