NBCn2 inhibitor Cmpd38J

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Chemical Structure : NBCn2 inhibitor Cmpd38J

Catalog No.: PC-27818Not For Human Use, Lab Use Only.

NBCn2 inhibitor Cmpd38J is a small molecule inhibitor of carbonate transporter NBCn2 (SLC4A10) with IC50 of 20.3 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NBCn2 inhibitor Cmpd38J is a small molecule inhibitor of carbonate transporter NBCn2 (SLC4A10) with IC50 of 20.3 uM.
Cmpd38J does not appear to affect sodium independent anion exchanger AE1 (SLC4A1) uptake activity, but does inhibit NDCBE(SLC4A8) with IC50 of 40.0 uM.
Cmpd38J inhibits NBCn2 in HEK cells with IC50 of 20 uM in the presence of 25mM NaHCO3.
Cmpd38J (80 uM) reduces miniature inhibitory postsynaptic currents (mIPSCs) in the hippocampus, recapitulating findings from NBCn2 knockout animals.

Physicochemical Properties

M.Wt	341.37
Formula	C17H19N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 2-(2-((3-methylbenzyl)amino)-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl)acetate

References

1. Yang S, et al. Nat Commun. 2026 Jul 22;17(1):8923.

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