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NC-005

Chemical Structure : NC-005

CAS No.: 1237540-74-7

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NC-005 (NC 005, NC005)

Catalog No.: PC-60970Not For Human Use, Lab Use Only.

NC-005 is a potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NC-005 is a potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely.
    NC-005 shows cytotoxicity against multiple myeloma cells with IC50 of 30 nM-1.5 uM.

    Physicochemical Properties

    M.Wt 663.815
    Formula C40H45N3O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-3-(4-methoxyphenyl)-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-(2-(naphthalen-2-yl)acetamido)propanamide

    References

    1. Britton M, et al. Chem Biol. 2009 Dec 24;16(12):1278-89.

    2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.

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