NCA029

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Chemical Structure : NCA029

Catalog No.: PC-23500Not For Human Use, Lab Use Only.

NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with EC50 of 0.2 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with EC50 of 0.2 uM.
NCA029 targeted HsClpP, inducing mitochondrial dysfunction and activating the ATF3-dependent integrated stress response, ultimately causing cell death in colorectal adenocarcinoma.
NCA029 displayed favorable pharmacokinetics and safety profiles and significantly inhibited tumor growth in HCT116 xenografts, resulting in 83.6% tumor inhibition.

Physicochemical Properties

M.Wt	399.42
Formula	C22H20F3N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-cyanobenzyl)-N-(4-(trifluoromethyl)benzyl)-1,2,5,6-tetrahydropyridine-3-carboxamide

References

1. Jiangnan Zhang, et al. J Med Chem. 2024 Feb 22;67(4):2812-2836.

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NCA029

Biological Activity

Physicochemical Properties

References

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