NCATS-SM0708

Chemical Structure : NCATS-SM0708

Catalog No.: PC-26953Not For Human Use, Lab Use Only.

NCATS-SM0708 is a potent, selective Aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor with biochemical IC50 of 13.62 nM in enzymatic assays, and cellular IC50 of 3.84 nM in ALDEFLUOR assays.

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Biological Activity

NCATS-SM0708 is a potent, selective Aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor with biochemical IC50 of 13.62 nM in enzymatic assays, and cellular IC50 of 3.84 nM in ALDEFLUOR assays.
NCATS-SM0708 demonstrates weak to inactive activity against ALDH1A1, ALDH1A2, ALDH2, and ALDH3A2, exhibiting moderate activity against ALDH1A3 (IC50 = 1.12 uM).

Physicochemical Properties

M.Wt	543.63
Formula	C26H24F3N5OS2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(2-methylthiazol-4-yl)benzyl)-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)thiazole-4-carboxamide

References

1. Sankalp Jain, et al. J Med Chem. 2026 May 30. doi: 10.1021/acs.jmedchem.6c00537.

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NCATS-SM0708

Biological Activity

Physicochemical Properties

References

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