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NCATS-SM4487

Chemical Structure : NCATS-SM4487

CAS No.: 2733617-81-5

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NCATS-SM4487 (NCATS-SM 4487)

Catalog No.: PC-72398Not For Human Use, Lab Use Only.

NCATS-SM4487 is a potent, small molecule inhibitor galactokinase (GALK1) with IC50 of 50 nM (hGALK1).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NCATS-SM4487 is a potent, small molecule inhibitor galactokinase (GALK1) with IC50 of 50 nM (hGALK1).
    NCATS-SM4487 prevents galactose-1 phosphate (gal-1P) accumulation in patient-derived cells at low micromolar concentrations and have pharmacokinetic properties suitable for evaluation in rodent models of galactosemia.

    Physicochemical Properties

    M.Wt 522.969
    Formula C25H24ClFN8O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((7-amino-6-fluorobenzo[d]oxazol-2-yl)amino)-4-(2-chloro-4-methylphenyl)-6-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1,4-dihydropyrimidine-5-carboxamide

    References

    1. Li Liu, et al. J Med Chem. 2021 Sep 23;64(18):13551-13571.

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