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NCD-38

Chemical Structure : NCD-38

CAS No.: 2078047-42-2

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NCD-38 (NCD38;NCD 38)

Catalog No.: PC-61955Not For Human Use, Lab Use Only.

NCD-38 is a novel potent, selective LSD1 inhibitor with IC50 of 0.59 uM, exerts highly selective inhibitory activity on LSD1 but no other enzymes, such as MAO (IC50>100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NCD-38 is a novel potent, selective LSD1 inhibitor with IC50 of 0.59 uM, exerts highly selective inhibitory activity on LSD1 but no other enzymes, such as MAO (IC50>100 uM).
    NCD-38 inhibits the growth of MLL-AF9 leukemia as well as erythroleukemia, megakaryoblastic leukemia and myelodysplastic syndromes (MDSs) overt leukemia cells.

    Physicochemical Properties

    M.Wt 680.165
    Formula C37H37ClF3N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    [1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-[[[(3-chlorophenyl)methyl]amino]carbonyl]-5-[[(1R,2S)-2-phenylcyclopropyl]amino]pentyl]-

    References

    1. Miyamura S, et al. Org Biomol Chem. 2016 Sep 28;14(36):8576-85.

    2. Sugino N, et al. Leukemia. 2017 Nov;31(11):2303-2314.

    3. Ogasawara D, et al. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8620-4.

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