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NCGC00238624

Chemical Structure : NCGC00238624

CAS No.: 2768230-55-1

NCGC00238624

Catalog No.: PC-26468Not For Human Use, Lab Use Only.

NCGC00238624 is a highly selective galactokinase (GALK1) inhibitor with IC50 of 7.69 and 13.67 uM against the human and mouse recombinant GALK1, respectively, lowers gal-1P levels in primary fibroblast cells derived from patients with classic galactosemia.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NCGC00238624 is a highly selective galactokinase (GALK1) inhibitor with IC50 of 7.69 and 13.67 uM against the human and mouse recombinant GALK1, respectively, lowers gal-1P levels in primary fibroblast cells derived from patients with classic galactosemia.

Physicochemical Properties

M.Wt 382.81
Formula C18H15ClN6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5(1H)-Quinazolinone, 2-(2-benzoxazolylamino)-4-(4-chloro-1H-pyrazol-3-yl)-4,6,7,8-tetrahydro-, (4R)-

References

1. Li Liu, et al. J Med Chem. 2021 Sep 23;64(18):13551-13571.

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