NCI-41356 | CRYAB inhibitor | Probechem Biochemicals

Chemical Structure : NCI-41356

NCI-41356 (NCI 41356)

Catalog No.: PC-20883Not For Human Use, Lab Use Only.

NCI-41356 is a small molecular inhibitor of αB-crystallin (CRYAB, HSPB5), significantly reducesthe interaction between CRYAB and VEGF165.

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Biological Activity

NCI-41356 is a small molecular inhibitor of αB-crystallin (CRYAB, HSPB5), significantly reducesthe interaction between CRYAB and VEGF165.
NCI-41356 (10-50 uM) decreases the malignant behaviour of breast tumour cells MDA-MB-231 and MDA-MB-436, does not alter CRYAB expression levels.
NCI-41356 (200 mg/kg, i.p.) greatly inhibits the tumour growth and vasculature development in in vivo human breast cancer xenograft models.

Physicochemical Properties

M.Wt	197.62
Formula	C6H12ClNO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R)-3-methylglutamic acid hydrochloride

References

1. Chen Z, et al. Breast Cancer Res Treat. 2014 May;145(1):45-59.

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NCI-41356 (NCI 41356)

Biological Activity

Physicochemical Properties

References

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