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NCT-505

Chemical Structure : NCT-505

CAS No.: 2231079-75-5

NCT-505 (NCT505, NCT 505)

Catalog No.: PC-35126Not For Human Use, Lab Use Only.

NCT-505 (NCT505) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases.

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Biological Activity

NCT-505 (NCT505) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases.
NCT-505 also exhibits IC50 of 30 nM in MIA PaCa-2 Aldefluor cell-based assays.
NCT-505 demonstrates target engagement in CETSA asssay (EC50=3.4 uM), inhibits the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiates the cytotoxicity of Paclitaxel in SKOV-3-TR, a Paclitaxel resistant ovarian cancer cell line.

Physicochemical Properties

M.Wt 635.635
Formula C29H29F4N5O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(6-Fluoro-3-(4-(methylsulfonyl)piperazine-1-carbonyl)quinolin-4-yl)-4-phenylpiperidine-4-carbonitrile, TFA

References

1. Yang SM, et al. J Med Chem. 2018 Jun 14;61(11):4883-4903.

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