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NCT02

Chemical Structure : NCT02

CAS No.: 790245-61-3

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NCT02 (CCNK-CDK12 degrader NCT02)

Catalog No.: PC-73186Not For Human Use, Lab Use Only.

NCT02 is a small moelcule that induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NCT02 is a small moelcule that induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12.
NCT02 decreases proliferation of CRC cells in vitro and tumor growth in vivo.
Pharmacological CCNK/CDK12 degradation via NCT02 is associated with TP53 deficiency and consensus molecular subtype 4 in vitro and in patient-derived xenografts.

Physicochemical Properties

M.Wt 312.387
Formula C17H16N2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)-

References

1. Sebastian M Dieter, et al. Cell Rep. 2021 Jul 20;36(3):109394.

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