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Chemical Structure : NCT02
CAS No.: 790245-61-3
Catalog No.: PC-73186Not For Human Use, Lab Use Only.
NCT02 is a small moelcule that induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $238 | In stock | |
| 10 mg | $378 | In stock | |
| 25 mg | $598 | In stock | |
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| 100 mg | Get quote |
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NCT02 is a small moelcule that induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12.
NCT02 decreases proliferation of CRC cells in vitro and tumor growth in vivo.
Pharmacological CCNK/CDK12 degradation via NCT02 is associated with TP53 deficiency and consensus molecular subtype 4 in vitro and in patient-derived xenografts.
| M.Wt | 312.387 | |
| Formula | C17H16N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)- |
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1. Sebastian M Dieter, et al. Cell Rep. 2021 Jul 20;36(3):109394.
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