Chemical Structure : ND-L11B TFA
CAS No.:
3078788-58-3
ND-L11B TFA
Catalog No.: PC-28193Not For Human Use, Lab Use Only.
ND-L11B TFA is an effective degrader of RE-IIBP and NSD2-long, effectively induces NSD2 degradation with DC50 of 1.48 and 0.80 uM in KMS11 MM cell line, reduces H3K36me2 level in cancer cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ND-L11B TFA is an effective degrader of RE-IIBP and NSD2-long, effectively induces NSD2 degradation with DC50 of 1.48 and 0.80 uM in KMS11 MM cell line, reduces H3K36me2 level in cancer cells.
ND-L11B treatment downregulated the expression of the NSD2-regulated genes known for their roles in cancer cell proliferation, metastasis and evasion, including: JAM2, MET, PAK1, RRAS2, BACE2, CA2, IGF2BP2, CR2.
ND-L11B exhibited stronger antiproliferative activity on multiple myeloma cell line (KMS11 MM cell, IC50=0.9 uM) and negligible effect on non-malignant normal cell line.
Physicochemical Properties
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M.Wt
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838.90
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Formula
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C39H52F6N10O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Acetamide, 2-[5-[5-[(3S)-3-amino-3-(2,2-difluoroethyl)-1-piperidinyl]-4-[(6-amino-9H-purin-9-yl)methyl]-2-pyridinyl]-2-fluorophenoxy]-N-(11-aminoundecyl)-, 2,2,2-trifluoroacetate (1:1)
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References
1. Hu L, et al. Eur J Med Chem. 2024 Dec 17;283:117179.
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