NDI-031407 | TYK2 inhibitor | Probechem Biochemicals

Chemical Structure : NDI-031407

NDI-031407 (NDI 031407)

Catalog No.: PC-72038Not For Human Use, Lab Use Only.

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Biological Activity

NDI-031407 (NDI 031407) is a novel potent, selective TYK2 inhibitor with IC50 of 0.21 nM in radiometric assays, 20 fold selectivity over JAK3 (4.2 nM), 147 fold for JAK2 (31 nM), and 220 fold for JAK1 (46 nM).
NDI-031407 has high potency in cell line and primary cell assays for TYK2-dependent cytokines (IL-12, IC50=118 nM) over TYK2-independent cytokines (GM-CSF).
NDI-031407 blocks IL-23–induced STAT3 phosphorylation and IL-17A production in human CD4+ T cells.
NDI-031407 inhibits disease progression in the SKG model of Spondyloarthritis (SpA).
NDI-031407 suppresses systemic IL-23–induced type 3 immunity in vivo.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
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Solubility
Chemical Name/SMILES

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NDI-031407 (NDI 031407)

Biological Activity

Physicochemical Properties

References

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