NDNA4

Chemical Structure : NDNA4

Catalog No.: PC-26414Not For Human Use, Lab Use Only.

NDNA4 is a potent, selective and cell-impermeable Hsp90α inhibitor with IC50 of 0.34 uM in FP assays, >294-fold selective over Hsp90β, Grp94 and Trap1.

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Biological Activity

NDNA4 is a potent, selective and cell-impermeable Hsp90α inhibitor with IC50 of 0.34 uM in FP assays, >294-fold selective over Hsp90β, Grp94 and Trap1.

Physicochemical Properties

M.Wt	604.69
Formula	C31H35F3N2O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Propanaminium, 3-[[2-[3-[(3,4-dimethylphenyl)thio]-4-hydroxybenzoyl]-2,3-dihydro-1H-isoindol-5-yl]oxy]-N,N,N-trimethyl-, 2,2,2-trifluoroacetate (1:1)

References

1. Reynolds TS, et al. ACS Med Chem Lett. 2023 Aug 8;14(9):1250-1256.

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NDNA4

Biological Activity

Physicochemical Properties

References

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