Chemical Structure : NEO214
CAS No.:
1361198-80-2
NEO214
(NEO-214;NEO 214)
Catalog No.: PC-36017Not For Human Use, Lab Use Only.
NEO214 (NEO-214) is a novel, BBB-permeable rolipram-perillyl alcohol conjugate, shows effectivity against both TMZ-sensitive and TMZ-resistant glioma cells (T98G IC50=40 uM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NEO214 (NEO-214) is a novel, BBB-permeable rolipram-perillyl alcohol conjugate, shows effectivity against both TMZ-sensitive and TMZ-resistant glioma cells (T98G IC50=40 uM).
NEO214 triggers apoptosis by activating the ER stress pathway, induces Death Receptor 5 (DR5) and TNF-related apoptosis inducing ligand (TRAIL/Apo2L) mediated cytotoxicity, without cytotoxicity to normal cells.
NEO214 is generated by covalently conjugating rolipram, a PDE4 (phosphodiesterase 4) inhibitor, to perillyl alcohol, a naturally occurring monoterpene related to limonene.
NEO214 decreases glioma progression in the in vivo mouse tumor model.
Physicochemical Properties
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M.Wt
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453.579
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Formula
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C27H35NO5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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((S)-4-(prop-1-en-2-yl)cyclohex-1-en-1-yl)methyl 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-oxopyrrolidine-1-carboxylate
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References
1. Cho HY, et al. Mol Cancer Ther. 2019 Jan 15. pii: molcanther.0465.2018.
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