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Chemical Structure : NEO214
Catalog No.: PC-36017Not For Human Use, Lab Use Only.
NEO214 (NEO-214) is a novel, BBB-permeable rolipram-perillyl alcohol conjugate, shows effectivity against both TMZ-sensitive and TMZ-resistant glioma cells (T98G IC50=40 uM).
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NEO214 (NEO-214) is a novel, BBB-permeable rolipram-perillyl alcohol conjugate, shows effectivity against both TMZ-sensitive and TMZ-resistant glioma cells (T98G IC50=40 uM).
NEO214 triggers apoptosis by activating the ER stress pathway, induces Death Receptor 5 (DR5) and TNF-related apoptosis inducing ligand (TRAIL/Apo2L) mediated cytotoxicity, without cytotoxicity to normal cells.
NEO214 is generated by covalently conjugating rolipram, a PDE4 (phosphodiesterase 4) inhibitor, to perillyl alcohol, a naturally occurring monoterpene related to limonene.
NEO214 decreases glioma progression in the in vivo mouse tumor model.
| M.Wt | 453.579 | |
| Formula | C27H35NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cho HY, et al. Mol Cancer Ther. 2019 Jan 15. pii: molcanther.0465.2018.
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