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Chemical Structure : NEO2734
CAS No.: 2081072-29-7
Catalog No.: PC-38169Not For Human Use, Lab Use Only.
NEO2734 (NEO-2734, EP31670) is a dual inhibitor of pan-BET and CBP/p300 with Kd values of 2-31 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $228 | In stock | |
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| 100 mg | Get quote |
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NEO2734 (NEO-2734, EP31670) is a dual inhibitor of pan-BET and CBP/p300 with Kd values of 2-31 nM.
NEO2734 exhibited in vitro antitumor activity in a variety of cancer cell lines derived from different tumor types, especially from prostate cancer, leukemias, and lymphomas.
NEO2734 showed a clear in vitro antitumor activity in DLBCL, which was more potent than either a BET inhibitor (birabresib) or a CBP/EP300 inhibitor (SGC-CBP30).
NEO2734 is active in both hotspot mutant (F133V) and non-hotspot mutant (Q165P) PCa cells in vitro and in vivo.
| M.Wt | 435.447 | |
| Formula | C22H24F3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,3-dimethyl-5-(2-(tetrahydro-2H-pyran-4-yl)-1-(2-(trifluoromethoxy)ethyl)-1H-benzo[d]imidazol-6-yl)pyridin-2(1H)-one |
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1. Yan Y, et al. EMBO Mol Med. 2019 Nov 7;11(11):e10659.
2. Spriano F, et al. Blood Adv. 2020 Sep 8;4(17):4124-4135.
3. Morrison-Smith CD, et al. Mol Cancer Ther. 2020 Jul;19(7):1406-1414.
4. He Y, et al. Nat Commun. 2021 Mar 9;12(1):1521.
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