Catalog No.: PC-72871Not For Human Use, Lab Use Only.
NERx 329 (RPAi 329, NERx329) is a novel potent, specific inhibitor of replication protein A (RPA), demonstrated potent RPA inhibitory activity in vitro, in vivo, and in cellular assays.
NERx 329 (RPAi 329, NERx329) is a novel potent, specific inhibitor of replication protein A (RPA), demonstrated potent RPA inhibitory activity in vitro, in vivo, and in cellular assays.
NERx 329 (RPAi 329) is specific for inhibiting the RPA ssDNA interaction, does not impact Escherichia coli single strand binding protein (SSB) with ssDNA
NERx 329 (RPAi 329) exhibited single-agent cellular anticancer activity in the H460 NSCLC cell line (IC50=3.5 uM), caused the degradation of replication forks upon stalling and RPA exhaustion.
NERx 329 (RPAi 329) demonstarted in vivo single-agent efficacy in H460 large cell carcinoma and A549 adenocarcinoma xenografts.
