NF-56-EJ40 | SUCNR1 (GPR91) antagonist

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Chemical Structure : NF-56-EJ40

CAS No.: 2380230-73-7

NF-56-EJ40 (SUCNR1 (GPR91) antagonist)

Catalog No.: PC-72374Not For Human Use, Lab Use Only.

NF-56-EJ40 is a highly potent, human-selective antagonist of SUCNR1 (GPR91) with IC50 of 25 nM and Ki of 33 nM.

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5 mg	$228	In stock
10 mg	$388	In stock
25 mg	$588	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NF-56-EJ40 is a highly potent, human-selective antagonist of SUCNR1 (GPR91) with IC50 of 25 nM and Ki of 33 nM.
NF-56-EJ40 is highly selective for human SUCNR1 and showed almost no activity towards rat SUCNR1.
NF-56-EJ40 significantly interrupt succinate/IL-1β signal in HUVECs and macrophages.

Physicochemical Properties

M.Wt	443.54
Formula	C27H29N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(4'-((4-Methylpiperazin-1-yl)methyl)-[1,1'-biphenyl]-3-carboxamido)phenyl)acetic acid

References

1. Matthias Haffke, et al. Nature. 2019 Oct;574(7779):581-585.

2. Jingwen Xu, et al. Front Immunol. 2022 Feb 22;13:817572.

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NF-56-EJ40 (SUCNR1 (GPR91) antagonist)

Biological Activity

Physicochemical Properties

References

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