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NF764

Chemical Structure : NF764

CAS No.:

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NF764 (CTNNB1 degrader NF764)

Catalog No.: PC-22501Not For Human Use, Lab Use Only.

NF764 is a potent and selective, covalent β-catenin (CTNNB1) binder and degrader wtih DC50 of 3.5 nM in HT29 cells (Emax=85%), targeting C619 of CTNNB1.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NF764 is a potent and selective, covalent β-catenin (CTNNB1) binder and degrader wtih DC50 of 3.5 nM in HT29 cells (Emax=85%), targeting C619 of CTNNB1.
NF764 inhibits CTNNB1 transcriptional activity, demonstrating functional inhibition of the WNT pathway in cells.
NF764 treatment significantly reduced the levels of CTNNB1 target genes,, including MYC, S100A6, AXIN2, and CCND1.
FLAG-CTNNB1 C619S mutation expressing HEK293T cells are completely resistant to NF764-mediated CTNNB1 loss.

Physicochemical Properties

M.Wt 403.40
Formula C22H20F3NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-1-(2-(5-methoxy-2-(trifluoromethyl)phenyl)pyrrolidin-1-yl)-4-phenylbut-2-ene-1,4-dione

References

1. Gowans FA, et al. J Am Chem Soc. 2024 Jun 6. doi: 10.1021/jacs.4c05174.

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