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Chemical Structure : NFAT-AP-1 interaction inhibitor 10
Catalog No.: PC-72977Not For Human Use, Lab Use Only.
NFAT-AP-1 interaction inhibitor 10 (NFAT inhibitor compound 10) is a small-molecule inhibitor nuclear factor of activated T cells (NFAT) with IC50 of 2 uM in FRET assays.
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NFAT-AP-1 interaction inhibitor 10 (NFAT inhibitor compound 10) is a small-molecule inhibitor nuclear factor of activated T cells (NFAT) with IC50 of 2 uM in FRET assays.
Compound 10 inhibits production of the cytokines IL-2 and TNF by total CD4+ murine T cells under conditions where it is not toxic to the cells.
NFAT inhibitor compound 10 inhibits formation of the quaternary NFAT:Fos:Jun:DNA complex on the ARRE-2 site, but not on the GM-330 element, without inhibiting the direct binding of NFAT or AP-1 to DNA.
Compound 10 alters the gene expression pattern of stimulated T cells and inhibits the expression of many NFAT-dependent genes, included Il2 and Nfatc1 (encoding NFAT2) short isoform, as well as Cd160, Erg1, and Xcl1, Nfkb1 (encoding NF-κB p50).
| M.Wt | 417.487 | |
| Formula | C22H19N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mognol GP, et al. Proc Natl Acad Sci U S A. 2019 Apr 24. pii: 201820604. doi: 10.1073/pnas.1820604116.
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