NGB-2904 | D3 receptor antagonist | Probechem Biochemicals

Chemical Structure : NGB-2904

NGB-2904 (NGB2904)

Catalog No.: PC-20863Not For Human Use, Lab Use Only.

NGB-2904 is a potent, highly selective dopamine D3 receptor antagonist with Ki of 2.0 nM for hD3, 56-fold selectivity over hD2.

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Biological Activity

NGB-2904 is a potent, highly selective dopamine D3 receptor antagonist with Ki of 2.0 nM for hD3, 56-fold selectivity over hD2.
NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats.
NGB 2904 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats.
NGB 2904 (1.0 mg/kg) stimulated spontaneous locomotion in wild-type mice, but was without measurable effect in dopamine D3 receptor knockout mice.

Physicochemical Properties

M.Wt	494.46
Formula	C28H29Cl2N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide

References

1. Martelle JL, et al. J Pharmacol Exp Ther. 2007 May;321(2):573-82.

2. Grundt P, et al. J Med Chem. 2005 Feb 10;48(3):839-48.

3. Xi ZX, et al. Neuropsychopharmacology. 2006 Jul;31(7):1393-405.

NGB-2904 (NGB2904)

Biological Activity

Physicochemical Properties

References

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