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Chemical Structure : NGB-2904
Catalog No.: PC-20863Not For Human Use, Lab Use Only.
NGB-2904 is a potent, highly selective dopamine D3 receptor antagonist with Ki of 2.0 nM for hD3, 56-fold selectivity over hD2.
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NGB-2904 is a potent, highly selective dopamine D3 receptor antagonist with Ki of 2.0 nM for hD3, 56-fold selectivity over hD2.
NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats.
NGB 2904 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats.
NGB 2904 (1.0 mg/kg) stimulated spontaneous locomotion in wild-type mice, but was without measurable effect in dopamine D3 receptor knockout mice.
| M.Wt | 494.46 | |
| Formula | C28H29Cl2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Martelle JL, et al. J Pharmacol Exp Ther. 2007 May;321(2):573-82.
2. Grundt P, et al. J Med Chem. 2005 Feb 10;48(3):839-48.
3. Xi ZX, et al. Neuropsychopharmacology. 2006 Jul;31(7):1393-405.
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