NGI-186

Chemical Structure : NGI-186

Catalog No.: PC-24839Not For Human Use, Lab Use Only.

NGI-186 is a potent, small molecule inhibitor of oligosaccharyltransferase (OST) with IC50 of 0.06 uM.

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Biological Activity

NGI-186 is a potent, small molecule inhibitor of oligosaccharyltransferase (OST) with IC50 of 0.06 uM.
NGI-186 demonstrates activity against both OST-A and OST-B, with preferential inhibition of OST-A.
NGI-186 induces great accumulation in the G1 phase of the cell cycle in PC-9 cells, causes induction of the pro-apoptotic protein, Bim, and again without an increase in phosphorylation of other RTKs.
NGI-186 inhibits EGFR N-glycosylation, blocks EGFR dependent signaling in EGFR mutant NSCLC.
NGI-186 (10 mg/kg, i.p.) reduces tumor growth in mice bearing MDA-MB-231-ERLucT xenografts.

Physicochemical Properties

M.Wt	464.60
Formula	C21H28N4O4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((cyclopropylmethyl)(methyl)amino)-N-(5-ethylthiazol-2-yl)-5-(morpholinosulfonyl)benzamide

References

1. Baro M, et al. Cell Chem Biol. 2025 Jun 19;32(6):839-853.e6.

NGI-186

Biological Activity

Physicochemical Properties

References

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