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NGI-1 derivative C-19

Chemical Structure : NGI-1 derivative C-19

CAS No.: 924471-88-5

NGI-1 derivative C-19

Catalog No.: PC-35568Not For Human Use, Lab Use Only.

NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A.

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    Biological Activity

    NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A.
    NGI-1 derivative C-19 reduces ligand stimulated activation of EGFR, in STT3A-ko cells, where EGFR glycosylation is dependent on STT3B alone, does not reduce glycosylation and ligand stimulation of EGFR in parental and STT3B-ko cells.
    NGI-1 derivative C-19 has discrete biological effects on endogenous STT3B target proteins such as COX2 but does not activate the cellular unfolded protein response (UPR).

    Physicochemical Properties

    M.Wt 415.508
    Formula C21H25N3O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(5-(morpholinosulfonyl)-2-(pyrrolidin-1-yl)phenyl)benzamide

    References

    1. Rinis N, et al. Cell Chem Biol. 2018 Jul 24. pii: S2451-9456(18)30232-0.

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