Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NH-23-C2
Catalog No.: PC-72960Not For Human Use, Lab Use Only.
NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.
NH-23-C2 displays off-reactivity with cysteine and threonine proteases (cathepsins B, L, V, S).
HCT116 cells were preincubated with NH-23-C2 inhibitor, MDM-2 cleavage was inhibited in a concentration-dependent manner (IC50 =3.11 μM).
NH-23-C2 selectively block caspase-2 activity and caspase-2-mediated MDM-2 cleavage.
| M.Wt | 845.903 | |
| Formula | C43H51N5O13 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Marcin Poreba, et al. Cell Death Differ. 2019 Dec;26(12):2695-2709.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
