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NIH-12848

Chemical Structure : NIH-12848

CAS No.: 959551-10-1

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NIH-12848 (NIH12848;NIH 12848)

Catalog No.: PC-42382Not For Human Use, Lab Use Only.

NIH-12848 is a potent and selective PI5P4Kγ inhibitor with IC50 of 1 uM, shows no significant inhibitory activity for PI5P4Kα and PI5P4Kβ (>100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NIH-12848 is a potent and selective PI5P4Kγ inhibitor with IC50 of 1 uM, shows no significant inhibitory activity for PI5P4Kα and PI5P4Kβ (>100 uM).
NIH-12848 inhibits the translocation of Na⁺/K⁺-ATPase to the plasma membrane in mpkCCD cells.
NIH-12848 is a potentially powerful tool for exploring the cell physiology of PI5P4Ks.

Physicochemical Properties

M.Wt 385.4054696
Formula C20H14F3N3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 28 mg/mL
Chemical Name/SMILES

4-Quinazolinamine, N-(2-thienylmethyl)-2-[2-(trifluoromethyl)phenyl]-

References

1. Clarke JH, et al. Biochem J. 2015 Mar 1;466(2):359-67.

2. Liang Q, et al. Nat Chem Biol. 2014 Apr;10(4):298-304.

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