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Chemical Structure : NIH-12848
CAS No.: 959551-10-1
Catalog No.: PC-42382Not For Human Use, Lab Use Only.
NIH-12848 is a potent and selective PI5P4Kγ inhibitor with IC50 of 1 uM, shows no significant inhibitory activity for PI5P4Kα and PI5P4Kβ (>100 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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NIH-12848 is a potent and selective PI5P4Kγ inhibitor with IC50 of 1 uM, shows no significant inhibitory activity for PI5P4Kα and PI5P4Kβ (>100 uM).
NIH-12848 inhibits the translocation of Na⁺/K⁺-ATPase to the plasma membrane in mpkCCD cells.
NIH-12848 is a potentially powerful tool for exploring the cell physiology of PI5P4Ks.
| M.Wt | 385.4054696 | |
| Formula | C20H14F3N3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
4-Quinazolinamine, N-(2-thienylmethyl)-2-[2-(trifluoromethyl)phenyl]- |
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1. Clarke JH, et al. Biochem J. 2015 Mar 1;466(2):359-67.
2. Liang Q, et al. Nat Chem Biol. 2014 Apr;10(4):298-304.
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