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Chemical Structure : NIO-1
Catalog No.: PC-72028Not For Human Use, Lab Use Only.
NIO-1 (Novel inhibitor of OCT1) is a novel small molecule inhibitor of Octamer transcription factor OCT1, inhibits OCT1 activation with IC50 of 0.11 uM.
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NIO-1 (Novel inhibitor of OCT1) is a novel small molecule inhibitor of Octamer transcription factor OCT1, inhibits OCT1 activation with IC50 of 0.11 uM.
NIO-1 repressed OCT1 activation by repressing recruitment of OCT1 to the binding sites of the promoter region of its downstream genes.
NIO-1 inhibited recruitment of OCT1 to the promoter region of its downstream genes containing OCT binding sites.
NIO-1 enhanced the sensitivity of ESCC cells to chemotherapeutic agents.
| M.Wt | 365.389 | |
| Formula | C20H19N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xiao-Zheng Zou, et al. Eur J Pharmacol. 2021 Sep 15;907:174222.
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